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Users need to know how to clean the iO table's housing, calibration plaque, and electrostatic mat.  

The Eye-One iO Quick Start Guide states the following cleaning instructions:

The plastic housing of the instrument may be cleaned with a damp cloth with some soap.  Clean the white reference with isopropyl alcohol on a soft clean cloth. The electrostatic mat of the iO should be cleaned with Isopropyl alcohol on a clean cloth. Alkaline solvents and soap should never be used to clean the electrostatic mat.

The Quick Start Guide can be accessed at:

http://my.xrite.com/documents/literature/en/i1iO_QuickStart_en.pdf

If the mat needs to be replaced, it will need to be returned to your local X-Rite Service Center.